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Synonyms: compound 12f [PMID: 12646019] | Palladiar® | PHA-291639 | PHA291639 | SU 11654 | SU-11654 | SU11654
Compound class: Synthetic organic
Comment: Toceranib (PHA-291639 and formerly SU11654) is a small molecule, multi-targeted receptor tyrosine kinase inhibitor . It is structurally related to sunitinib. Targets include VEGFRs, FGFR, PDGFRs, and Kit (including constitutively active mutant forms ). Like sunitinib, toceranib has antiangiogenic and anitproliferative actions. Palladiar® branded toceranib is used to treat solid tumours in dogs.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖