fomepizole   Click here for help

GtoPdb Ligand ID: 11705

Synonyms: 4-methylpyrazole | Antizol®
Approved drug PDB Ligand
fomepizole is an approved drug (FDA (1997))
Compound class: Synthetic organic
Comment: Fomepizole is an alcohol dehydrogenase inhibitor.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 28.68
Molecular weight 82.05
XLogP 0.97
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Cc1c[nH]nc1
Isomeric SMILES Cc1c[nH]nc1
InChI InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChI Key RIKMMFOAQPJVMX-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Fomepizole is used as an antidote to poisonings with ethylene glycol or methanol. It prevents conversion of these alcohols into their toxic metabolites oxalate and formic acid respectively.