triprolidine   Click here for help

GtoPdb Ligand ID: 1228

Synonyms: Actidil®
Approved drug
triprolidine is an approved drug (FDA (1982))
Compound class: Synthetic organic
Comment: Marketed formulations often contained triprolidine hydrochloride, but many of these have been discontinued.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 16.13
Molecular weight 278.18
XLogP 4.01
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccc(cc1)C(=CCN1CCCC1)c1ccccn1
Isomeric SMILES Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1
InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
No information available.
Summary of Clinical Use Click here for help
Used for the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis, allergic conjunctivitis and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Marketing of the brand Actidil® has been discontinued in the US.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Binds to the histamine H1 receptor, blocking the action of endogenous histamine, leading to the temporary relief of symptoms induced by histamine agonism of the receptors.
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