sulfametrole is an approved drug
Compound class:
Synthetic organic
Comment: Sulfametrole is a sulfonamide antibacterial compound.
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No information available. |
Summary of Clinical Use |
Oral or intravenous formulations of sulfametrole + trimethoprim are authorised in several European countries as an alternative to co-trimoxazole. There is no information regarding approval for clinical use of this drug on the US FDA website. |
Mechanism Of Action and Pharmacodynamic Effects |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants [2]. The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis [1]. |