ABBV-154

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Ligands
ABBV-154

GtoPdb Ligand ID: 12918

Synonyms: ADC11 [1]

Comment: ABBV-154 is a investigational antibody-drug conjugate (ADC) in which a glucocorticoid receptor modulator (GRM) payload is linked to the anti-TNαF antibody adalimumab[1]. It is very similar to ABBV-3373 but has a phosphate prodrug version of the GRM to provide improved stability. ABBV-154 was designed to modulate TNF-mediated inflammatory pathways by delivering the glucocorticoid directly into activated immune cells that express membrane-bound TNFα, as a treatment for immune-mediated diseases such as rheumatoid arthritis.

Summary
Biological activity
Clinical data
References

No information available.

No information available.

Summary of Clinical Use
Clinical studies in Crohn's disease, rheumatoid arthritis and polymyalgia rheumatica have all been terminated, and it appears that development of ABBV-154 has been discontinued.

Summary of Clinical Use

Clinical studies in Crohn's disease, rheumatoid arthritis and polymyalgia rheumatica have all been terminated, and it appears that development of ABBV-154 has been discontinued.