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Synonyms: ADC11 [1]
Compound class:
Antibody
Comment: ABBV-154 is a investigational antibody-drug conjugate (ADC) in which a glucocorticoid receptor modulator (GRM) payload is linked to the anti-TNαF antibody adalimumab[1]. It is very similar to ABBV-3373 but has a phosphate prodrug version of the GRM to provide improved stability. ABBV-154 was designed to modulate TNF-mediated inflammatory pathways by delivering the glucocorticoid directly into activated immune cells that express membrane-bound TNFα, as a treatment for immune-mediated diseases such as rheumatoid arthritis.
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| References |
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1. Hobson AD, Xu J, Welch DS, Marvin CC, McPherson MJ, Gates B, Liao X, Hollmann M, Gattner MJ, Dzeyk K et al.. (2023)
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC). J Med Chem, 66 (17): 12544-12558. [PMID:37656698] |
