nalorphine   Click here for help

GtoPdb Ligand ID: 1629

Synonyms: N-allyl-normorphine
Approved drug
nalorphine is an approved drug
Compound class: Synthetic organic
Comment: This drug does not have marketing approval in the US or European Union. Other national approval agencies may have granted marketing authorisation. In some countries nalorphine may only be used in veterinary practice.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 52.93
Molecular weight 311.15
XLogP 1.1
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES C=CCN1CCC23C4C1Cc1c3c(OC2C(C=C4)O)c(cc1)O
Isomeric SMILES C=CCN1CC[C@@]23[C@@H]4[C@H]1Cc1c3c(O[C@H]2[C@H](C=C4)O)c(cc1)O
InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1
No information available.
Summary of Clinical Use Click here for help
Previously used to reverse opioid overdose and in a challenge test to determine opioid dependence.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
μ opioid receptor antagonist, κ receptor agonist.