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Synonyms: Natpar® | Natpara® | rhPTH[1-84]
PTH is an approved drug (FDA (2015), EMA (2017))
Compound class:
Endogenous peptide in human, mouse or rat
Comment: In its recombinant form, human parathyroid hormone was approved for clinical use in 2015, under the name Natpara.
The amino acid sequence provided here is the mature peptide, with the signal (MIPAKDMAKVMIVMLAICFLTKSDG) and propeptide (KSVKKR) domains removed.
Species: Human
View more information in the IUPHAR Pharmacology Education Project: pth |
| No information available. |
Summary of Clinical Use  |
| Approved for use in patients with hypoparathyroidism to control low blood calcium levels. |
| Mechanism Of Action and Pharmacodynamic Effects |
| PTH increases levels of calcium in the blood through its interaction with the PTH1 receptor. |
| External links |
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For extended ADME data see the following: Drugs.com European Medicines Agency (EMA) |
