perphenazine   Click here for help

GtoPdb Ligand ID: 209

Synonyms: Decentan® | Fentazin® | Trilafon®
Approved drug
perphenazine is an approved drug (FDA (1957))
Compound class: Synthetic organic
Comment: Perphenazine is a typical antipsychotic drug, acting principally as a dopamine D2 receptor antagonist.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: perphenazine

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 55.25
Molecular weight 403.15
XLogP 3.86
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
Isomeric SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
InChI InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
No information available.
Summary of Clinical Use Click here for help
Perphenazine is an antipsychotic used to treat schizophrenia. Also used for the management of severe nausea and vomiting in adults.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Antipsychotic action arises from antagonism of neuronal dopamine D1/D2 receptors. But also has affinity for 5-HT2A , D3, D4 and histamine H1 receptors. Antagonism of dopamine D2 receptors in the vomiting centre and chemoreceptor trigger zone (CTZ) leads to the antiemetic effect of this drug.
External links Click here for help