Synonyms: Ansyr® | CP-165331 / CP-16533-1 | Securon®
verapamil is an approved drug (FDA (1981))
Compound class:
Synthetic organic
Comment: The approved drug verapamil is a racemic mixture of two enantiomers (PubChem CID 92305 and PubChem CID 65808). The structure shown here does not specify stereochemistry and represents the mixture. Marketed formulations may contain verapamil hydrochloride (PubChem CID 62969).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: verapamil |
|
No information available. |
Summary of Clinical Use |
Used therapeutically as a calcium channel blocker in the treatment of cardiac arrhythmia, hypertension and angina. |
Mechanism Of Action and Pharmacodynamic Effects |
A class IV antiarrhythmic agent, verapamil decreases impulse conduction through the AV node. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com |