Synonyms: Ansyr® | CP-165331 / CP-16533-1 | Securon®
verapamil is an approved drug (FDA (1981))
Compound class:
Synthetic organic
Comment: The approved drug verapamil is a racemic mixture of two enantiomers (PubChem CID 92305 and PubChem CID 65808). The structure shown here does not specify stereochemistry and represents the mixture. Marketed formulations may contain verapamil hydrochloride (PubChem CID 62969).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: verapamil |
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References |
1. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. (2002)
Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet, 10 (1): 36-43. [PMID:11896454] |
2. Baumann L, Gerstner A, Zong X, Biel M, Wahl-Schott C. (2004)
Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci, 45 (2): 708-13. [PMID:14744918] |
3. Cang C, Bekele B, Ren D. (2014)
The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat Chem Biol, 10 (6): 463-9. [PMID:24776928] |
4. Engel K, Wang J. (2005)
Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol, 68 (5): 1397-407. [PMID:16099839] |
5. Gupta S, Cohen KA, Winglee K, Maiga M, Diarra B, Bishai WR. (2014)
Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis. Antimicrob Agents Chemother, 58 (1): 574-6. [PMID:24126586] |
6. Johnson BD, Hockerman GH, Scheuer T, Catterall WA. (1996)
Distinct effects of mutations in transmembrane segment IVS6 on block of L-type calcium channels by structurally similar phenylalkylamines. Mol Pharmacol, 50 (5): 1388-400. [PMID:8913371] |
7. Kofuji P, Hofer M, Millen KJ, Millonig JH, Davidson N, Lester HA, Hatten ME. (1996)
Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells. Neuron, 16 (5): 941-52. [PMID:8630252] |
8. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. (2000)
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol Renal Physiol, 278 (6): F1013-21. [PMID:10836990] |
9. Madeja M, Müller V, Musshoff U, Speckmann EJ. (2000)
Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamil. Neuropharmacology, 39 (2): 202-10. [PMID:10670415] |
10. Tarabova B, Lacinova L, Engel J. (2007)
Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells. Eur J Pharmacol, 573 (1-3): 39-48. [PMID:17651721] |
11. Viljoen A, Raynaud C, Johansen MD, Roquet-Banères F, Herrmann JL, Daher W, Kremer L. (2019)
Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages. Antimicrob Agents Chemother, 63 (9). [PMID:31209005] |
12. Walsh KB, Bryant SH, Schwartz A. (1986)
Effect of calcium antagonist drugs on calcium currents in mammalian skeletal muscle fibers. J Pharmacol Exp Ther, 236 (2): 403-7. [PMID:2418195] |
13. Wang J. (2016)
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition. Clin Pharmacol Ther, 100 (5): 489-499. [PMID:27506881] |
14. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J et al.. (2012)
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell, 151 (2): 372-83. [PMID:23063126] |
15. Yeo KR, Yeo WW. (2001)
Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes. Br J Clin Pharmacol, 51 (5): 461-70. [PMID:11422004] |