fampridine   Click here for help

GtoPdb Ligand ID: 2416

Synonyms: 4-aminopyridine | 4-AP | Ampyra® | EL-970
Approved drug
fampridine is an approved drug (FDA (2010), EMA (2011))
Compound class: Synthetic organic
Comment: Fampridine is the INN for this compound, whereas its USAN is dalfampridine.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 94.05
XLogP -0.05
No. Lipinski's rules broken 0
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Canonical SMILES Nc1ccncc1
Isomeric SMILES Nc1ccncc1
InChI InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
No information available.
Summary of Clinical Use Click here for help
Approved to improve walking ability in adults with multiple sclerosis (MS) whose walking is impaired [10,15].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Fampridine blocks voltage-gated potassium channels on nerve fibres. When these channels are prevented from functioning on MS damaged nerves, potassium ions are retained within the nerve cells and this is believed to facilitate propogation of the electrical impulse along the nerves to the muscles. This improved muscle stimulation then makes walking easier.
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