mosapride   Click here for help

GtoPdb Ligand ID: 242

Approved drug
mosapride is an approved drug
Compound class: Synthetic organic
Comment: Marketed formulations contain mosapride citrate (PubChem CID 119583).
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 76.82
Molecular weight 421.16
XLogP 2.93
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl
Isomeric SMILES CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl
InChI InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
No information available.
Summary of Clinical Use Click here for help
Mosapride is not approved by the US FDA or EMA. Other national approval agencies (mainly in South America and East Asia) have authorised its clinical use. Where approved, mosapride is used to treat gastrointestinal disorders [2], as it acts to accelerate gastric emptying.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Mosapride a selective agonist of the serotonin 5-HT4 receptor [3].