prucalopride   Click here for help

GtoPdb Ligand ID: 243

Synonyms: Motegrity® | R-093877 | R-108512 | Resolor®
Approved drug
prucalopride is an approved drug (EMA (2009), FDA (2018))
Compound class: Synthetic organic
Comment: Prucalopride is a serotonin 5-HT4 receptor agonist.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: prucalopride

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 76.82
Molecular weight 367.17
XLogP 1.56
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N
Isomeric SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N
InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
No information available.
Summary of Clinical Use Click here for help
Prucalopride is a once-daily, oral treatment that is approved as an option for adult patients with chronic constipation (including chronic idiopathic constipation) for whom laxatives are not effective.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The 5-HT4 receptor subtype is physiologically and pathophysiologically important for the regulation of intestinal peristalsis and gut motility [1,6-7]. Activation of these receptors in the gut wall enhances the peristaltic reflex [4], relaxes the smooth muscle and increases fluid secretion in the gastrointestinal (GI) tract [5]. All of these actions improve transit in GI functional disorders.
External links Click here for help