Abbreviated name: RTX
Compound class:
Natural product
Comment: Resiniferatoxin, an extract from resin spurge (Euphorbia resinifera), is a TRPV1 agonist.
There is some ambiguity online and in the literature as to the exact stereochemistry of resiniferatoxin. The representation shown here matches that in the PubChem and ChEMBL links above, while several tautomers and stereoisomers are also listed on PubChem, and ChEBI represents the compound with the entry CHEBI:8809. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use ![]() |
Clinical trials NCT00804154 (Phase 1) and NCT02522611 (Phase 1/2) which have both suspended participant recruitment, were designed to evaluate intrathecal/preganglionic administration of resiniferatoxin as therapy for severe (intractable) pain in patients with advanced cancer. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
The rationale for using resiniferatoxin as pain control is reviewed in [4]. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT00804154 | Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer | Phase 1 Interventional | National Institutes of Health Clinical Center (CC) | ||
NCT02522611 | Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain | Phase 1/Phase 2 Interventional | National Institutes of Health Clinical Center (CC) |