Ligand id: 2491

Name: resiniferatoxin

Abbreviated name: RTX

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 120.75
Molecular weight 628.27
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. (1997)
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
Nature, 389 (6653): 816-24. [PMID:9349813]
2. Correll CC, Phelps PT, Anthes JC, Umland S, Greenfeder S. (2004)
Cloning and pharmacological characterization of mouse TRPV1.
Neurosci. Lett., 370 (1): 55-60. [PMID:15489017]
3. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol. Pharmacol., 45 (6): 1227-34. [PMID:7517498]
4. Iadarola MJ, Mannes AJ. (2011)
The vanilloid agonist resiniferatoxin for interventional-based pain control.
Curr Top Med Chem, 11 (17): 2171-9. [PMID:21671877]
5. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J. Biol. Chem., 273 (10): 5851-7. [PMID:9488722]
6. Smart D, Jerman JC, Gunthorpe MJ, Brough SJ, Ranson J, Cairns W, Hayes PD, Randall AD, Davis JB. (2001)
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.
Eur. J. Pharmacol., 417 (1-2): 51-8. [PMID:11301059]