propafenone   Click here for help

GtoPdb Ligand ID: 2561

Synonyms: Arythmol® | GNF-Pf-4594 | Rythmol®
Approved drug
propafenone is an approved drug (FDA (1989))
Compound class: Synthetic organic
Comment: Marketed formulations may contain propafenone hydrochloride (PubChem CID 36708).
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View more information in the IUPHAR Pharmacology Education Project: propafenone

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 58.56
Molecular weight 341.2
XLogP 3.23
No. Lipinski's rules broken 1
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Canonical SMILES CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O
Isomeric SMILES CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O
InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used in the management of atrial arrhythmias to prolong the time between reoccurences of paroxysmal atrial fibrillation/flutter. Also used in the treatment of ventricular arrhythmias.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
For an overview of the mechanism of action of propafenone, please see the DrugBank entry linked to from this ligand page.
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