propafenone   Click here for help

GtoPdb Ligand ID: 2561

Synonyms: Arythmol® | GNF-Pf-4594 | Rythmol®
Approved drug
propafenone is an approved drug (FDA (1989))
Compound class: Synthetic organic
Comment: Marketed formulations may contain propafenone hydrochloride (PubChem CID 36708).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 58.56
Molecular weight 341.2
XLogP 3.23
No. Lipinski's rules broken 1
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Canonical SMILES CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O
Isomeric SMILES CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O
InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
1. Auerbach SS, DrugMatrix® and ToxFX® Coordinator National Toxicology Program. 
National Toxicology Program: Dept of Health and Human Services.
Accessed on 02/05/2014. Modified on 02/05/2014. DrugMatrix,
2. Franqueza L, Valenzuela C, Delpón E, Longobardo M, Caballero R, Tamargo J. (1998)
Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels.
Br J Pharmacol, 125 (5): 969-78. [PMID:9846634]