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Synonyms: 7-epipaclitaxel | Abraxane® (albumin-bound suspension) | Taxol®
paclitaxel is an approved drug (FDA (1992), EMA (2008))
Compound class: Natural product or derivative
Comment: Paclitaxel is a tubulin inhibitor. It was originally identified and isolated from the bark of the Pacific yew, Taxus brevifolia (hence the name 'taxol', and naming of the taxane family of compounds- includes docetaxel and cabazitaxel). The drug can be administered as a solvent-based drug, or in a formulation called nab-paclitaxel. Nab-paclitaxel consists of paclitaxel bound to albumin nanoparticles as a delivery vehicle (trade name Abraxane)- nab stands for nanoparticle albumin-bound.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: paclitaxel
|No information available.|
|Summary of Clinical Use|
|Solvent-based paclitaxel is approved to treat lung, ovarian and breast cancers and Kaposi's sarcoma.
Nab-paclitaxel is designated as an orphan drug by the US FDA, for the treatment of metastatic adenocarcinoma of the pancreas (in combination with gemcitabine). It is fully approved for this indication and for use in certain breast cancer patients (with tumours unresponsive to other chemotherapy, or relapsed disease) and non-small-cell lung cancer (NSCLC).
|Mechanism Of Action and Pharmacodynamic Effects|
|Paclitaxel binds to the β-subunit of tubulin, which prevents the microtubule/paclitaxel complex from disassembling. This prevents normal microtubulin growth and function by stopping the microtubules from shortening and lengthening as they normally would.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)