- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: 7-epipaclitaxel | Abraxane® (albumin-bound suspension) | Taxol®
paclitaxel is an approved drug (FDA (1992), EMA (2008))
Compound class: Natural product or derivative
Comment: Paclitaxel is a tubulin inhibitor. It was originally identified and isolated from the bark of the Pacific yew, Taxus brevifolia (hence the name 'taxol', and naming of the taxane family of compounds- includes docetaxel and cabazitaxel). The drug can be administered as a solvent-based drug, or in a formulation called nab-paclitaxel. Nab-paclitaxel consists of paclitaxel bound to albumin nanoparticles as a delivery vehicle (trade name Abraxane)- nab stands for nanoparticle albumin-bound.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: paclitaxel
1. Backman JT, Filppula AM, Niemi M, Neuvonen PJ. (2016)
Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.
Pharmacol Rev, 68 (1): 168-241. [PMID:26721703]
2. Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M. (2000)
Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol.
J Biol Chem, 275 (4): 2251-4. [PMID:10644670]
3. Ouyang X, Piatnitski EL, Pattaropong V, Chen X, He HY, Kiselyov AS, Velankar A, Kawakami J, Labelle M, Smith 2nd L et al.. (2006)
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Bioorg Med Chem Lett, 16 (5): 1191-6. [PMID:16377187]
4. Synold TW, Dussault I, Forman BM. (2001)
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.
Nat Med, 7 (5): 584-90. [PMID:11329060]
5. Zeldin DC, DuBois RN, Falck JR, Capdevila JH. (1995)
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Arch Biochem Biophys, 322 (1): 76-86. [PMID:7574697]