Ligand id: 2820

Name: raloxifene

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View more information in the IUPHAR Pharmacology Education Project: raloxifene

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 98.24
Molecular weight 473.17
XLogP 5.65
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
For the prevention and treatment of osteoporosis in post-menopausal women, and the prevention and treatment of corticosteroid-induced bone loss. Also used for the reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis or those who have a high risk of breast cancer development.
Mechanism Of Action and Pharmacodynamic Effects
Estrogen receptor modulator, producing estrogen-like effects on bone which results in reduced resorption of bone and increased bone mineral density in postmenopausal women. For a complete overview of the mechanism of aciton of raloxifene, please see the DrugBank entry linked to from this ligand page.
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