Synonyms: Evista® | LY-156758 | Optruma® | raloxifene hydrochloride
raloxifene is an approved drug (FDA (1997), EMA (1998))
Compound class:
Synthetic organic
Comment: Raloxifene is a selective estrogen receptor modulator (SERM).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: raloxifene |
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References |
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2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor. Bioorg Med Chem Lett, 11 (14): 1939-42. [PMID:11459665] |
2. Ishii Y, Takeuchi K. (2018)
Therapeutic agent for nonalcoholic fatty liver disease. Patent number: WO2018198842A1. Assignee: National University Corporation Kyushu University. Priority date: 14/04/2018. Publication date: 01/11/2018. |
3. Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA. (1997)
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology, 138 (3): 863-70. [PMID:9048584] |
4. Petrie WK, Dennis MK, Hu C, Dai D, Arterburn JB, Smith HO, Hathaway HJ, Prossnitz ER. (2013)
G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet Gynecol Int, 2013: 472720. [PMID:24379833] |
5. Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS, Katzenellenbogen JA. (2000)
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem, 43 (26): 4934-47. [PMID:11150164] |