risedronate   Click here for help

GtoPdb Ligand ID: 3176

Synonyms: Actonel® | Atelvia® | NE-58095 | risedronate sodium
Approved drug PDB Ligand
risedronate is an approved drug (FDA (1998))
Compound class: Synthetic organic
Comment: Risedronate is a bisphosphonate drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 4
Topological polar surface area 167.8
Molecular weight 283
XLogP -3.62
No. Lipinski's rules broken 0
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Canonical SMILES OP(=O)(C(P(=O)(O)O)(Cc1cccnc1)O)O
Isomeric SMILES OP(=O)(C(P(=O)(O)O)(Cc1cccnc1)O)O
InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
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Summary of Clinical Use Click here for help
Bisphosphonate drug used to strenghten bone in the treatment of Pagets's disease and the prevention or treatment of osteoporosis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Risedronate acts by inhibiting osteoclast activity and reduces boen reabsorption and turnover. This is due to its affinity for bone mineral matrix component hydroxyapatite, and its inhibition of enzyme farnesyl diphosphate synthase (FPP synthase). FPP synthase inhibition prevents with synthesis of the isoprenoid lipids farnesyl diphosphate and geranylgeranyl diphosphate which are involved in post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins.
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