gallamine   Click here for help

GtoPdb Ligand ID: 356

Synonyms: Flaxedil®
Approved drug PDB Ligand
gallamine is an approved drug
Compound class: Synthetic organic
Comment: The approved drug contains three iodine ions and is called gallamine triethiodide. This drug is known as a nondepolarizing neuromuscular blocking drug (NDMRD).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 21
Topological polar surface area 27.69
Molecular weight 510.46
XLogP 4.29
No. Lipinski's rules broken 1
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Canonical SMILES CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC
Isomeric SMILES CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC
InChI InChI=1S/C30H60N3O3/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9/h19-21H,10-18,22-27H2,1-9H3/q+3
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Summary of Clinical Use Click here for help
This drug is used to induce skeletal muscle relaxation during anesthesic and mechanical ventilation procedures. Note that there is no information regarding approval for medical use of gallamine triethiodide on the US FDA website. Individual national agencies may have granted marketing approval.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Gallamine is an antagonist of muscle-type nicotinic acetylcholine receptors. The drug antagonises acetylcholine action at muscarinic acetylcholine receptors in the muscle end-plate and prevents activation of the muscle contraction process.