Synonyms: 3,4-dihydroxy-L-phenylalanine | Inbrija® (levodopa inhalation powder) | L-DOPA | Sinemet®
levodopa is an approved drug (FDA (1993), EMA (2003))
Compound class:
Metabolite
Comment: L-DOPA is the precursor to the neurotransmitters dopamine collectively known as catecholamines. Used in the treatment of Parkisons disease. Note a deuterated derivative D3 L-DOPA with enhanced properties is under development.
![]() View more information in the IUPHAR Pharmacology Education Project: levodopa |
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No information available. |
Summary of Clinical Use ![]() |
Used in the treatment of Parkinson's disease. The 2003 EMA approval authorises the use of levodopa in a fixed-dose combination with carbidopa and entacapone (called Stalevo®). The EMA has also approved a combination containing just levodopa and carbidopa (Numient®, 2015). |
External links ![]() |
For extended ADME data see the following: European Medicines Agency (EMA) |