hexamethonium   Click here for help

GtoPdb Ligand ID: 3963

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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 0
Molecular weight 202.24
XLogP 0.97
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES C[N+](CCCCCC[N+](C)(C)C)(C)C
Isomeric SMILES C[N+](CCCCCC[N+](C)(C)C)(C)C
InChI InChI=1S/C12H30N2/c1-13(2,3)11-9-7-8-10-12-14(4,5)6/h7-12H2,1-6H3/q+2
InChI Key VZJFGSRCJCXDSG-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Hexamethonium was used to treat chronic hypertension, but use has been discontinued. No information regarding international approval status is available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Hexamethonium acts as negative allosteric modulator of nicotinic acetylcholine receptor activity in sympathetic and parasympathetic ganglia.