aniracetam   Click here for help

GtoPdb Ligand ID: 4133

Approved drug PDB Ligand
aniracetam is an approved drug
Compound class: Synthetic organic
Comment: Based on this compound's allosteric action on AMPA receptor activity [1] it was used as the structural basis for the development of novel potential ampakines. These compounds are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease (AD) and other neurodegenerative conditions (see patent US6730677).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 46.61
Molecular weight 219.09
XLogP 1.33
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc(cc1)C(=O)N1CCCC1=O
Isomeric SMILES COc1ccc(cc1)C(=O)N1CCCC1=O
InChI InChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
No information available.
Summary of Clinical Use Click here for help
Aniracetam is not approved by the US FDA or EMA. It is approved for use in some countries.
Aniracetam is used for its nootropic (cognition-enhancing) and central stimulant effects.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Aniracetam's anxiolytic action may be mediated through dopamine D2, nicotinic acetylcholine, and serotonin 5-HT2A receptors [2]. This compound also allosterically potentiates AMPA receptor activity [1].