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aniracetam is an approved drug
Compound class: Synthetic organic
Comment: Based on this compound's allosteric action on AMPA receptor activity  it was used as the structural basis for the development of novel potential ampakines. These compounds are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease (AD) and other neurodegenerative conditions (see patent US6730677).
1. Ito I, Tanabe S, Kohda A, Sugiyama H. (1990)
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
J Physiol (Lond.), 424: 533-43. [PMID:1975272]
2. Nakamura K, Kurasawa M. (2001)
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Eur J Pharmacol, 420 (1): 33-43. [PMID:11412837]