cyclothiazide   Click here for help

GtoPdb Ligand ID: 4167

Synonyms: Anhydron® | Aquirel®
Approved drug
cyclothiazide is an approved drug
Compound class: Synthetic organic
Comment: Cyclothiazide functions primarily as an inhibior of the sodium-chloride symporter (SLC12A3) in distal convoluted tubules.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 135.12
Molecular weight 389.03
XLogP 1.59
No. Lipinski's rules broken 0
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Canonical SMILES Clc1cc2NC(NS(=O)(=O)c2cc1S(=O)(=O)N)C1CC2CC1C=C2
Isomeric SMILES Clc1cc2NC(NS(=O)(=O)c2cc1S(=O)(=O)N)C1CC2CC1C=C2
InChI InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
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Summary of Clinical Use Click here for help
Cyclothiazide is used to treat edema caused by disease (eg congestive heart failure or hepatic cirrhosis) or other drug therapy (eg corticosteroid or estrogen hormone therapy) and may also be used to manage hypertension. Cyclothiazide does not appear to have marketing approval for human use in the US or EU, although individual countries may have approved use of this drug.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Cyclothiazide is a diuretic, inhibiting water reabsorption in the nephron. The molecular mechanism includes cyclothiazide-induced inhibition of the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule. In addition the drug is reported to allosterically regulate glutamate receptors and enhance glutamate responses [1,3-4].