Ligand id: 4167

Name: cyclothiazide

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 135.12
Molecular weight 389.03
XLogP 1.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Deng L, Chen G. (2003)
Cyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses.
Proc. Natl. Acad. Sci. U.S.A., 100 (22): 13025-9. [PMID:14534329]
2. Miu P, Jarvie KR, Radhakrishnan V, Gates MR, Ogden A, Ornstein PL, Zarrinmayeh H, Ho K, Peters D, Grabell J et al.. (2001)
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro.
Neuropharmacology, 40 (8): 976-83. [PMID:11406188]
3. Skolnick P, Palfreyman MG, Reynolds IJ. (1994)
Direct and allosteric control of glutamate receptors.  In  
Edited by Skolnick P, Palfreyman MG, Reynolds IJ (CRC Press) 174. [ISBN:0849383072.]
4. Yamada KA, Tang CM. (1993)
Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.
J. Neurosci., 13 (9): 3904-15. [PMID:8103555]