flurbiprofen   

GtoPdb Ligand ID: 4194

Synonyms: Ansaid® | Froben®
flurbiprofen is an approved drug (FDA (1986))
Compound class: Synthetic organic
Comment: Flurbiprofen is member of the nonsteroidal anti-inflammatory drug (NSAID) family. It has antipyretic and analgesic activity.
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 244.09
XLogP 3.76
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)C(c1ccc(c(c1)F)c1ccccc1)C
Isomeric SMILES OC(=O)C(c1ccc(c(c1)F)c1ccccc1)C
InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI Key SYTBZMRGLBWNTM-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Flurbiprofen is approved to treat the pain and inflammation associated with rheumatic diseases and other musculoskeletal disorders, as well as dysmenorrhoea, migraine and as postoperative analgesia.
Mechanism Of Action and Pharmacodynamic Effects
Flurbiprofen reversibly inhibits cyclooxygenase (COX) enzymes 1 and 2, causing a reduction in synthesis of pro-inflammatory prostaglandins.