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Synonyms: Ansaid® | Froben®
flurbiprofen is an approved drug (FDA (1986))
Compound class: Synthetic organic
Comment: Flurbiprofen is member of the nonsteroidal anti-inflammatory drug (NSAID) family. It has antipyretic and analgesic activity.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: flurbiprofen
1. Bayly CI, Black WC, Léger S, Ouimet N, Ouellet M, Percival MD. (1999)
Structure-based design of COX-2 selectivity into flurbiprofen.
Bioorg. Med. Chem. Lett., 9 (3): 307-12. [PMID:10091674]
2. Voilley N, de Weille J, Mamet J, Lazdunski M. (2001)
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
J. Neurosci., 21 (20): 8026-33. [PMID:11588175]
3. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR. (1999)
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
Proc. Natl. Acad. Sci. U.S.A., 96 (13): 7563-8. [PMID:10377455]