zolpidem   Click here for help

GtoPdb Ligand ID: 4348

Synonyms: Ambien® | SL 80.0750-23N | SL-80.0750-23N | Stilnoct®
Approved drug PDB Ligand
zolpidem is an approved drug (FDA (1992))
Compound class: Synthetic organic
Comment: Marketed formulations contain zolpidem tartrate (PubChem CID 18004026).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 37.61
Molecular weight 307.17
XLogP 3.98
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccc(cc1)c1nc2n(c1CC(=O)N(C)C)cc(cc2)C
Isomeric SMILES Cc1ccc(cc1)c1nc2n(c1CC(=O)N(C)C)cc(cc2)C
InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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Summary of Clinical Use Click here for help
A sedative or hypnotic agent used in the treatment of insomnia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Zolpidem is an agonist of the GABAA receptor with highest affinity at the α1 subunit. The positive modulation of the GABAA receptor complex by zolpidem increases its affinity for GABA.
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