zolpidem   Click here for help

GtoPdb Ligand ID: 4348

Synonyms: Ambien® | SL 80.0750-23N | SL-80.0750-23N | Stilnoct®
Approved drug PDB Ligand
zolpidem is an approved drug (FDA (1992))
Compound class: Synthetic organic
Comment: Marketed formulations contain zolpidem tartrate (PubChem CID 18004026).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 37.61
Molecular weight 307.17
XLogP 3.98
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccc(cc1)c1nc2n(c1CC(=O)N(C)C)cc(cc2)C
Isomeric SMILES Cc1ccc(cc1)c1nc2n(c1CC(=O)N(C)C)cc(cc2)C
InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
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Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.
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Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits.
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International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans.
Pharmacol Rev, 70 (4): 836-878. [PMID:30275042]