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Synonyms: ABBOTT-70569 | ABT-569 | Gabitril® | tiagabine hydrochloride
tiagabine is an approved drug (FDA (1997))
Compound class: Synthetic organic
Comment: Tiagabine is classified as a GABA reuptake inhibitor (GRI) as it blocks the GABA transporter 1 (GAT-1; gene symbol SLC6A1).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: tiagabine
|No information available.
|Summary of Clinical Use
|Tiagabine is an anticonvulsant medication used in the treatment of partial seizures and as an adjunctive treatment for epilepsy.
|Mechanism Of Action and Pharmacodynamic Effects
|The exact mechanism of action of tiagabine is unknown, however it is believed to operate as a selective GABA reuptake inhibitor.
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)