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Ligand id: 488
View more information in the IUPHAR Pharmacology Education Project: tamsulosin
Molecular properties generated using the CDK
|No information available.|
|Summary of Clinical Use|
|Used in the symptomatic relief of benign prostatic hyperplasia.
A 2015 report indicates that tamsulosin increases expulsion of larger (>10mm) kidney stones  in a double-blind, placebo-controlled, randomized, multicenter clinical trial. This result suggests that terazosin and doxazosin, which belong to the same drug class, may provide the same effect.
|Mechanism Of Action and Pharmacodynamic Effects|
|Selective antagonist for α1A- and α1D-adrenoceptors in the prostate, prostatic capsule, prostatic uretha and bladder neck causing relaxation of smooth muscles and therefore decreasing urinary outflow resistance in men.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)