tamsulosin

Ligand id: 488

Name: tamsulosin

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 108.26
Molecular weight 408.17
XLogP 2.32
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
α1A-adrenoceptor Hs Antagonist Antagonist 10.0 – 10.7 pKi - 1-3,5-6
pKi 10.0 – 10.7 [1-3,5-6]
α1D-adrenoceptor Hs Antagonist Antagonist 9.8 – 10.2 pKi - 3,5-6
pKi 9.8 – 10.2 [3,5-6]
α1B-adrenoceptor Hs Antagonist Inverse agonist 9.5 – 9.7 pKi - 3,5-6
pKi 9.5 – 9.7 [3,5-6]
Ligand mentioned in the following text fields