brain natriuretic peptide   Click here for help

GtoPdb Ligand ID: 4890

Abbreviated name: BNP
Synonyms: BNP(1-32) | BNP-32 | brain natriuretic peptide 32 | Natrecor®
Approved drug
brain natriuretic peptide is an approved drug (FDA (2001))
Comment: Nesiritide is the recombinant form of human brain natriuretic peptide.
Species: Human
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Summary of Clinical Use Click here for help
Nesiritide is used to relaxe and dilate blood vessels, lowering blood pressure. The drug is also used to improve breathing in patients with congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
In its natural form, the endogenous peptide BNP binds to the guanylate cyclase receptor in vascular smooth muscle and endothelial cells. This leads to the relaxation of smooth muscle through increasing intracellular concentrations of guanosine 3'5'-cyclic monophosphate. This in turn leads to the dilation of veins and arteries.