brain natriuretic peptide

Abbreviated name: BNP

Synonyms: BNP(1-32) | BNP-32 | brain natriuretic peptide 32 | Natrecor®

brain natriuretic peptide is an approved drug (FDA (2001))

Compound class: Endogenous peptide in human, mouse or rat

Comment: Nesiritide is the recombinant form of human brain natriuretic peptide.

Species: Human

View more information in the IUPHAR Pharmacology Education Project: brain natriuretic peptide

Bioactivity Comments
There appears to be no publicly available bioactivity data for this drug at its human molecular target.

Bioactivity Comments

There appears to be no publicly available bioactivity data for this drug at its human molecular target.

Natural/Endogenous Targets

Target
Guanylyl cyclase-A

Selectivity at catalytic receptors

Key to terms and symbols

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Target			Sp.	Type	Action	Value	Parameter	Concentration range (M)	Reference
Guanylyl cyclase-A			Hs	Agonist	Binding	-	-	-	1
⤷	[1]

Additional information and targets (data relate to human unless otherwise stated)
Description	Data	Reference
Potency order at Guanylyl cyclase-A	atrial natriuretic peptide (NPPA, P01160) ≥ brain natriuretic peptide (NPPB, P16860) >> C-type natriuretic peptide (NPPC, P23582)	2
Potency order at Guanylyl cyclase-B	C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860)	2
Potency order at natriuretic peptide receptor 3	atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860)	2