Li+

Ligand id: 5212

Name: Li+

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Summary of Clinical Use
Lithium is used as a mood stabilizer in the treatment of bipolar disorder counteracting both mania and depression. Lithium may also be used to prevent migraine and cluster headaches [3].
Mechanism Of Action and Pharmacodynamic Effects
Current evidence suggests that lithium may act through two molecular pathways to exert its beneficial effects. These are both enzymatic pathways:
1. inhibition of inositol monophosphatase within the phosphatidylinositol signalling pathway
2. inhibition of the protein kinase glycogen synthase kinase 3 in Wnt/β-catenin signalling
In both cases lithium is believed to inhibit the enzymes by displacing the normal regulatory co-factor Mg2+ [5]. The evidence behind these mechanisms is reviewed in [1].