Li+   Click here for help

GtoPdb Ligand ID: 5212

Synonyms: lithium ion
Approved drug
Li+ is an approved drug (FDA (1970))
Compound class: Inorganic
Comment: Lithium is a long-standing psychiatric medicine of unclear mechanism. A number of enzymes have been proposed as potential targets of lithium action, including inositol monophosphatase, a family of structurally related phosphomonoesterases, and the protein kinase glycogen synthase kinase-3 (see [4] and the DrugBank link). Administered as salt formulations such as the carbonate PubChem CID 11125
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Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IMPase 1 Primary target of this compound Hs Inhibitor Inhibition 3.5 pKi - 2
pKi 3.5 [2]
glycogen synthase kinase 3 beta Hs Inhibitor Inhibition 2.6 pIC50 - 6
pIC50 2.6 (IC50 2.5x10-3 M) Competive with Mg2+ [6]
Ligand mentioned in the following text fields