Ligand id: 5429

Name: adapalene

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 46.53
Molecular weight 412.2
XLogP 8.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Adapalene is a retinoid, applied topically to treat acne.
As of July 2016, a 0.1% adapalene gel has FDA approval as the first retinoid available for over-the-counter sales.
Mechanism Of Action and Pharmacodynamic Effects
Activation of nuclear retinoic acid receptors (RARβ and γ) is believed to reduce the pore blockage that causes acne lesions. This effect is achieved through normalisation of the differentiation of follicular cells in the epithelium, which may be aberrant in the pathogenesis of acne.