terbutaline   Click here for help

GtoPdb Ligand ID: 560

Synonyms: Brethine® | Bricanyl® | KWD-2019 | terbutalin
Approved drug
terbutaline is an approved drug (FDA (1974))
Compound class: Synthetic organic
Comment: Terbutaline is a fast-acting β2-adrenoceptor agonist (sympathomimetic) drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 72.72
Molecular weight 225.14
XLogP 1.42
No. Lipinski's rules broken 0
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Canonical SMILES OC(c1cc(O)cc(c1)O)CNC(C)(C)C
Isomeric SMILES OC(c1cc(O)cc(c1)O)CNC(C)(C)C
InChI InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3
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Summary of Clinical Use Click here for help
Used in the prevention and reversal of bronchospasm in reversible, obstructive airway disease and management of bronchospasm associated with bronchitis and emphysema. Also used for the inhibition of uterine contractions in cases of premature labour.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Stimulates intracellular adenyl cyclase which results in increased levels of cAMP resulting in bronchial smooth muscle relaxation and inhibition of the release of mediators of immediate hypersensitivity from mast cells.
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