terbutaline   Click here for help

GtoPdb Ligand ID: 560

Synonyms: Brethine® | Bricanyl® | KWD-2019 | terbutalin
Approved drug
terbutaline is an approved drug (FDA (1974))
Compound class: Synthetic organic
Comment: Terbutaline is a fast-acting β2-adrenoceptor agonist (sympathomimetic) drug.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: terbutaline

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 72.72
Molecular weight 225.14
XLogP 1.42
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES OC(c1cc(O)cc(c1)O)CNC(C)(C)C
Isomeric SMILES OC(c1cc(O)cc(c1)O)CNC(C)(C)C
InChI InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
β2-adrenoceptor Primary target of this compound Hs Agonist Partial agonist 5.5 – 5.6 pKi - 1-2
pKi 5.5 – 5.6 [1-2]
β1-adrenoceptor Hs Agonist Partial agonist 3.9 pKi - 2
pKi 3.9 [2]
β2-adrenoceptor Hs Agonist Partial agonist 7.3 pEC50 - 2
pEC50 7.3 [2]
β1-adrenoceptor Hs Agonist Partial agonist 5.8 pEC50 - 2
pEC50 5.8 [2]
Ligand mentioned in the following text fields