vipadenant   Click here for help

GtoPdb Ligand ID: 5612

Synonyms: BIIB 014 | BIIB014 | V2006
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Vipadenant is an adenosine A2 receptor antagonist that can promote T cell activation. It was originally investigated as a potential therapeutic for Parkinson's disease but development for this indication was discontinued at Phase 2 [2].
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 121.67
Molecular weight 321.13
XLogP 1.2
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N
Isomeric SMILES Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N
InChI InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20)
No information available.
Summary of Clinical Use Click here for help
Click here to link to's full list of vipadenant (BIIB014) trials.