perindopril   Click here for help

GtoPdb Ligand ID: 6367

Synonyms: Coversyl® | Preterax® | S-9490
Approved drug
perindopril is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Prodrug metabolically converted to the drug perindoprilat. Perindopril erbumine [USAN] aka perindopril tert-butylamine, is PubChem CID 441313.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 95.94
Molecular weight 368.23
XLogP 2.58
No. Lipinski's rules broken 0
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Isomeric SMILES CCC[C@@H](C(=O)OCC)N[C@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O)C
InChI InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
No information available.
Summary of Clinical Use Click here for help
Perindopril is an ACE inhibitor used to treat hypertension, congestive heart failure, post-myocardial infarction and coronary disease.
Perindopril is also a component of Prestalia®, a mixture of perindopril and amlodipine, a drug approved (by the US FDA in 2015) for the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Converted in the liver to active metabolite perindoprilat. Inhibits the conversion of angiotensin I to angiotensin II, which in turn decreases blood pressure. Also causes an increase in plasma renin activity.
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