Synonyms: CGS-14824A | Lotensin®
benazepril is an approved drug (FDA (1991))
Compound class:
Synthetic organic
Comment: Benazepril (an ACE inhibitor) is administered as an ester is a prodrug, which is metabolized by the liver into its active form benazeprilat.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: benazepril |
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No information available. |
Summary of Clinical Use |
Angiotensin-converting-enzyme inhibitor (ACE inhibitor) used to treat hypertension, congestive heart failure and chronic renal failure. |
Mechanism Of Action and Pharmacodynamic Effects |
Inhibition of ACE acts on the renin-angiotensin-aldosterone system (RAAS) to relax blood vessels which leads to a reduction in blood pressure. |
Pharmacokinetics |
Biotransformation/Metabolism |
The ester group is cleaved in the liver, converting benazepril into its active form benazeprilat. |