Ligand id: 6466

Name: cipemastat

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 110.26
Molecular weight 436.27
XLogP 1.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This compound was being investigated as a treatment for rheumatoid arthritis [2] and as a tumor growth inhibitor [3]. It failed in Phase I clinical trials.
Mechanism Of Action and Pharmacodynamic Effects
Cipemastat inhibits matrix metalloproteinase-1 activity.