Ligand id: 6466

Name: cipemastat

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 110.26
Molecular weight 436.27
XLogP 1.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Close DR. (2001)
Matrix metalloproteinase inhibitors in rheumatic diseases.
Ann. Rheum. Dis., 60 Suppl 3: iii62-7. [PMID:11890658]
2. Hemmings FJ, Farhan M, Rowland J, Banken L, Jain R. (2001)
Tolerability and pharmacokinetics of the collagenase-selective inhibitor Trocade in patients with rheumatoid arthritis.
Rheumatology (Oxford), 40 (5): 537-43. [PMID:11371662]
3. Lein M, Jung K, Ortel B, Stephan C, Rothaug W, Juchem R, Johannsen M, Deger S, Schnorr D, Loening S et al.. (2002)
The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model.
Oncogene, 21 (13): 2089-96. [PMID:11960381]