bambuterol   Click here for help

GtoPdb Ligand ID: 6601

Synonyms: Bambec® | Oxeol®
Approved drug
bambuterol is an approved drug
Compound class: Synthetic organic
Comment: Bambuterol has marketing approval in many countries but is not approved for sale in the US or UK.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 91.34
Molecular weight 367.21
XLogP 1.36
No. Lipinski's rules broken 0
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Canonical SMILES O=C(N(C)C)Oc1cc(cc(c1)OC(=O)N(C)C)C(CNC(C)(C)C)O
Isomeric SMILES O=C(N(C)C)Oc1cc(cc(c1)OC(=O)N(C)C)C(CNC(C)(C)C)O
InChI InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3
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Summary of Clinical Use Click here for help
Bambuterol is a long acting β-adrenoceptor agonist used as an anti-asthmatic. It is a prodrug of terbutaline.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Stimulation of β-adrenergic receptors increases intracellular cyclic AMP levels and causes relaxation of bronchial smooth muscle and inhibits release of causative agents of allergic reaction, such as histamine, leukotriene and prostaglandin from surrounding cells, especially mast cells.